High Throughput Screening for Inhibitors of Alpha-Galactosidase
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چکیده
منابع مشابه
High Throughput Screening for Inhibitors of Alpha-Galactosidase
Fabry disease is a rare X-linked lysosomal storage disorder caused by a deficiency in α-galactosidase A (GLA), which catalyzes the hydrolysis of terminal α-galactosyl groups from glycosphingolipids, such as globotriaosylceramide (Gb3). Many of the mutations in the GLA gene are missense alterations that cause misfolding, decreased stability, and/or mistrafficking of this protein. Small molecule ...
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ژورنال
عنوان ژورنال: Current Chemical Genomics
سال: 2010
ISSN: 1875-3973
DOI: 10.2174/1875397301004010067